ASCC1 Antibody, HRP conjugated (PACO25085)
- SKU:
- PACO25085
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ASCC1 Antibody, HRP conjugated (PACO25085) |
抗体コード: | PACO25085 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Activating signal cointegrator 1 complex subunit 1 protein (1-315AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. |
シノニム: | Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50), ASCC1 |
UniProt Protein Function: | ASCC1: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Defects in ASCC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in ASCC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10pter-q25.3 Cellular Component: transcription factor complex; cytoplasm Molecular Function:RNA binding Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent Disease: Barrett Esophagus |
NCBI Summary: | This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q8N9N2 |
NCBI GenInfo Identifier: | 311771708 |
NCBI Gene ID: | 51008 |
NCBI Accession: | NP_001185727.1 |
UniProt Secondary Accession: | Q8N9N2,Q5SW06, Q5SW07, Q96EI8, Q9Y307, |
UniProt Related Accession: | Q8N9N2 |
Molecular Weight: | 41,228 Da |
NCBI Full Name: | activating signal cointegrator 1 complex subunit 1 isoform b |
NCBI Synonym Full Names: | activating signal cointegrator 1 complex subunit 1 |
NCBI Official Symbol: | ASCC1 |
NCBI Official Synonym Symbols: | p50; CGI-18; ASC1p50 |
NCBI Protein Information: | activating signal cointegrator 1 complex subunit 1 |
UniProt Protein Name: | Activating signal cointegrator 1 complex subunit 1 |
UniProt Synonym Protein Names: | ASC-1 complex subunit p50; Trip4 complex subunit p50 |
Protein Family: | Activating signal cointegrator 1 complex |
UniProt Gene Name: | ASCC1 |
UniProt Entry Name: | ASCC1_HUMAN |