ARPC3 Antibody (PACO31656)
- SKU:
- PACO31656
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARPC3 Antibody (PACO31656) |
抗体コード: | PACO31656 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Actin-related protein 2/3 complex subunit 3 protein (2-175AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: ARPC3 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 21 kDa Observed band size: 75 kDa . |
![]() | Immunohistochemistry analysis of human tonsil tissue using PACO31656 at dilution of 1:100. |
![]() | Immunohistochemistry analysis of human testis tissue using PACO31656 at dilution of 1:100. |
バックグラウンド: | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
シノニム: | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC), ARPC3, ARC21 |
UniProt Protein Function: | ARPC3: one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. |
UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: Arp2/3 protein complex; focal adhesion; membrane; lamellipodium; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility |
NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
UniProt Code: | O15145 |
NCBI GenInfo Identifier: | 3121765 |
NCBI Gene ID: | 10094 |
NCBI Accession: | O15145.3 |
UniProt Secondary Accession: | O15145,O00554, |
UniProt Related Accession: | O15145 |
Molecular Weight: | 178 |
NCBI Full Name: | Actin-related protein 2/3 complex subunit 3 |
NCBI Synonym Full Names: | actin related protein 2/3 complex, subunit 3, 21kDa |
NCBI Official Symbol: | ARPC3 |
NCBI Official Synonym Symbols: | ARC21; p21-Arc |
NCBI Protein Information: | actin-related protein 2/3 complex subunit 3; arp2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21 |
UniProt Protein Name: | Actin-related protein 2/3 complex subunit 3 |
UniProt Synonym Protein Names: | Arp2/3 complex 21 kDa subunit; p21-ARC |
Protein Family: | Actin-related protein 2/3 complex |
UniProt Gene Name: | ARPC3 |
UniProt Entry Name: | ARPC3_HUMAN |