ARL6IP1 Antibody (PACO15533)
- SKU:
- PACO15533
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARL6IP1 Antibody (PACO15533) |
抗体コード: | PACO15533 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human ARL6IP1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15533(ARL6IP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15533(ARL6IP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | ARMER (apoptotic regulator in the membrane of the endoplasmic reticulum), also known as ADP-ribosylation-like factor 6-interacting protein 1 (ARL6IP1 or AIP1), is a multi-pass membrane protein that belongs to the Ras superfamily. It is expressed in brain, thymus, lung, bone marrow and, to a lesser extent, in spleen, kidney and liver. ARMER is not found in the heart and is found predominantly in early myeloid progenitor cells localizing to the intracytoplasmic membranes. It interacts with ARL6, inhibits caspase-9 activity by inhibiting proteolysis of downstream substrates (including LEHD-AFC, vimentin and caspase-3) and is down-regulated during myeloid differentiation. ARMER may play a role in membrane trafficking, protein transport or cell signaling during hematopoietic maturation. |
シノニム: | ADP-ribosylation factor-like 6 interacting protein 1 |
UniProt Protein Function: | ARL6IP: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Belongs to the ARL6ip family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16p12-p11.2 Cellular Component: membrane; integral to membrane; translocon complex; cytosol Molecular Function:protein binding Biological Process: cotranslational protein targeting to membrane Disease: Spastic Paraplegia 61, Autosomal Recessive |
NCBI Summary: | This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q15041 |
NCBI GenInfo Identifier: | 14424435 |
NCBI Gene ID: | 23204 |
NCBI Accession: | Q15041.2 |
UniProt Secondary Accession: | Q15041,B7Z6S5, B7Z791, F5GXP4, |
UniProt Related Accession: | Q15041 |
Molecular Weight: | 17,158 Da |
NCBI Full Name: | ADP-ribosylation factor-like protein 6-interacting protein 1 |
NCBI Synonym Full Names: | ADP-ribosylation factor-like 6 interacting protein 1 |
NCBI Official Symbol: | ARL6IP1 |
NCBI Official Synonym Symbols: | AIP1; ARMER; SPG61; ARL6IP |
NCBI Protein Information: | ADP-ribosylation factor-like protein 6-interacting protein 1; aip-1; ARL-6-interacting protein 1; apoptotic regulator in the membrane of the endoplasmic reticulum |
UniProt Protein Name: | ADP-ribosylation factor-like protein 6-interacting protein 1 |
Protein Family: | ADP-ribosylation factor-like protein 6-interacting protein |
UniProt Gene Name: | ARL6IP1 |
UniProt Entry Name: | AR6P1_HUMAN |
Antibodies |
Anti-ARL6IP1 Antibody (CAB17107) |
Anti-ARL6IP1 Antibody (CAB19995)[KO Validated] |
ARL6IP1 Antibody (PACO07848) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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