ARHGEF9 Antibody (PACO13369)
- SKU:
- PACO13369
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARHGEF9 Antibody (PACO13369) |
抗体コード: | PACO13369 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human ARHGEF9-Specific |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | Cdc42 guanine nucleotide exchange factor (GEF) 9;ARHGEF9;COLLYBISTIN;HPEM-2;KIAA0424;PEM-2;PEM2 ; |
UniProt Protein Function: | ARHGEF9: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8). A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: Xq11.1 Cellular Component: cytoplasm; cytosol Molecular Function:guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction Disease: Epileptic Encephalopathy, Early Infantile, 8 |
NCBI Summary: | The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] |
UniProt Code: | O43307 |
NCBI GenInfo Identifier: | 111599692 |
NCBI Gene ID: | 23229 |
NCBI Accession: | BC117406 |
UniProt Secondary Accession: | O43307,Q5JSL6, A8K1S8, B4DHC7, F8W7P8, |
UniProt Related Accession: | O43307 |
Molecular Weight: | 49,458 Da |
NCBI Full Name: | Homo sapiens Cdc42 guanine nucleotide exchange factor (GEF) 9, mRNA |
NCBI Synonym Full Names: | Cdc42 guanine nucleotide exchange factor 9 |
NCBI Official Symbol: | ARHGEF9 |
NCBI Official Synonym Symbols: | PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN |
NCBI Protein Information: | rho guanine nucleotide exchange factor 9 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 9 |
UniProt Synonym Protein Names: | Collybistin; PEM-2 homolog; Rac/Cdc42 guanine nucleotide exchange factor 9 |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF9 |
UniProt Entry Name: | ARHG9_HUMAN |