ARHGEF5 Antibody, FITC conjugated (PACO46524)
- SKU:
- PACO46524
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | ARHGEF5 Antibody, FITC conjugated (PACO46524) |
抗体コード: | PACO46524 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Rho guanine nucleotide exchange factor 5 protein (433-507AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). |
シノニム: | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM), ARHGEF5, TIM |
UniProt Protein Function: | ARHGEF5: 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: 7q35 Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:GTP binding; guanyl-nucleotide exchange factor activity; protein binding Biological Process: positive regulation of JNK activity; positive regulation of stress fiber formation; positive regulation of transcription factor activity; regulation of actin cytoskeleton organization and biogenesis; regulation of cytoskeleton organization and biogenesis; regulation of GTPase activity |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12774 |
NCBI GenInfo Identifier: | 290457679 |
NCBI Gene ID: | 7984 |
NCBI Accession: | Q12774.3 |
UniProt Secondary Accession: | Q12774,Q6ZML7, A6NNJ2, |
UniProt Related Accession: | Q12774 |
Molecular Weight: | 60,056 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 5 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 5 |
NCBI Official Symbol: | ARHGEF5 |
NCBI Official Synonym Symbols: | P60; TIM; GEF5; TIM1 |
NCBI Protein Information: | rho guanine nucleotide exchange factor 5 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 5 |
UniProt Synonym Protein Names: | Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF5 |
UniProt Entry Name: | ARHG5_HUMAN |