ARHGEF11 Antibody (PACO56314)
- SKU:
- PACO56314
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARHGEF11 Antibody (PACO56314) |
抗体コード: | PACO56314 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
反応性: | Human |
免疫原: | Recombinant Human Rho guanine nucleotide exchange factor 11 protein (1221-1318AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO56314 diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. |
シノニム: | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF), ARHGEF11, KIAA0380 |
UniProt Protein Function: | ARHGEF11: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; cytosol; intracellular Molecular Function:G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15085 |
NCBI GenInfo Identifier: | 34395516 |
NCBI Gene ID: | 9826 |
NCBI Accession: | O15085.1 |
UniProt Secondary Accession: | O15085,Q5VY40, Q6PFW2, D3DVD0, |
UniProt Related Accession: | O15085 |
Molecular Weight: | 172,244 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 11 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 11 |
NCBI Official Symbol: | ARHGEF11 |
NCBI Official Synonym Symbols: | GTRAP48; PDZ-RHOGEF |
NCBI Protein Information: | rho guanine nucleotide exchange factor 11 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 11 |
UniProt Synonym Protein Names: | PDZ-RhoGEF |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF11 |
UniProt Entry Name: | ARHGB_HUMAN |