ARHGDIB Antibody (PACO07828)
- SKU:
- PACO07828
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARHGDIB Antibody (PACO07828) |
抗体コード: | PACO07828 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human ARHGDIB |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | Rho GDP dissociation inhibitor (GDI) β;ARHGDIB;D4;GDIA2;GDID4;LYGDI;Ly-GDI;RAP1GN1;RhoGDI2 ; |
UniProt Protein Function: | RhoGDI beta: regulates the GDP/GTP exchange reaction of Rho proteins by inhibiting the dissociation of GDP from them, keeping these small GTPases in an inactive state. The GDIs are made up of two domains: a flexible N-terminal domain of about 70 amino acid residues and a folded 134-residue C-terminal domain. Regulates the GTP/GDP cycling of glucose-responsive small GTPases. Its phosphorylation on Y156, S101, and S174 mediates the cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. Interacts with WNK1. |
UniProt Protein Details: | Protein type:G protein regulator, misc.; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: cytoskeleton; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol Molecular Function:Rho GDP-dissociation inhibitor activity; GTPase activator activity Biological Process: regulation of small GTPase mediated signal transduction; regulation of catalytic activity; small GTPase mediated signal transduction; multicellular organismal development; immune response; negative regulation of cell adhesion; cell motility; actin cytoskeleton organization and biogenesis; Rho protein signal transduction; positive regulation of GTPase activity |
NCBI Summary: | Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010] |
UniProt Code: | P52566 |
NCBI GenInfo Identifier: | 1707893 |
NCBI Gene ID: | 397 |
NCBI Accession: | P52566.3 |
UniProt Secondary Accession: | P52566,B5BU79, |
UniProt Related Accession: | P52566 |
Molecular Weight: | 201 |
NCBI Full Name: | Rho GDP-dissociation inhibitor 2 |
NCBI Synonym Full Names: | Rho GDP dissociation inhibitor (GDI) beta |
NCBI Official Symbol: | ARHGDIB |
NCBI Official Synonym Symbols: | D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2 |
NCBI Protein Information: | rho GDP-dissociation inhibitor 2; Rho GDI 2; rho-GDI beta |
UniProt Protein Name: | Rho GDP-dissociation inhibitor 2 |
UniProt Synonym Protein Names: | Ly-GDI; Rho-GDI beta |
Protein Family: | Rho GDP-dissociation inhibitor |
UniProt Gene Name: | ARHGDIB |
UniProt Entry Name: | GDIR2_HUMAN |