ARHGAP4 Antibody (PACO19152)
- SKU:
- PACO19152
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARHGAP4 Antibody (PACO19152) |
抗体コード: | PACO19152 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human ARHGAP4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19152(ARHGAP4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19152(ARHGAP4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. |
シノニム: | Rho GTPase activating protein 4 |
UniProt Protein Function: | ARHGAP4: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; cytosol Molecular Function:GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rac GTPase binding; Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity Biological Process: cytoskeleton organization and biogenesis; negative regulation of cell migration; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
NCBI Summary: | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
UniProt Code: | P98171 |
NCBI GenInfo Identifier: | 258613907 |
NCBI Gene ID: | 393 |
NCBI Accession: | NP_001158213.1 |
UniProt Secondary Accession: | P98171,Q14144, Q86UY3, |
UniProt Related Accession: | P98171 |
Molecular Weight: | 109,393 Da |
NCBI Full Name: | rho GTPase-activating protein 4 isoform 1 |
NCBI Synonym Full Names: | Rho GTPase activating protein 4 |
NCBI Official Symbol: | ARHGAP4 |
NCBI Official Synonym Symbols: | C1; RGC1; p115; SrGAP4; RhoGAP4 |
NCBI Protein Information: | rho GTPase-activating protein 4 |
UniProt Protein Name: | Rho GTPase-activating protein 4 |
UniProt Synonym Protein Names: | Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; p115 |
UniProt Gene Name: | ARHGAP4 |