ARFRP1 Antibody (PACO58156)
- SKU:
- PACO58156
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARFRP1 Antibody (PACO58156) |
抗体コード: | PACO58156 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human ADP-ribosylation factor-related protein 1 protein (1-201AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO58156 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. |
シノニム: | ADP-ribosylation factor-related protein 1 (ARF-related protein 1) (ARP), ARFRP1, ARP1 |
UniProt Protein Function: | AGO4: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily. |
UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 1p34 Cellular Component: cytoplasm; cytosol; membrane Molecular Function:double-stranded RNA binding; miRNA binding; protein binding; single-stranded RNA binding Biological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; mRNA catabolic process; phosphoinositide-mediated signaling; pre-microRNA processing; RNA secondary structure unwinding; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway |
NCBI Summary: | The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012] |
UniProt Code: | Q13795 |
NCBI GenInfo Identifier: | 4507449 |
NCBI Gene ID: | 10139 |
NCBI Accession: | NP_003215 |
UniProt Related Accession: | Q13795 |
Molecular Weight: | 97 |
NCBI Full Name: | ADP-ribosylation factor-related protein 1 isoform a |
NCBI Synonym Full Names: | ADP ribosylation factor related protein 1 |
NCBI Official Symbol: | ARFRP1 |
NCBI Official Synonym Symbols: | ARP; Arp1; ARL18 |
NCBI Protein Information: | ADP-ribosylation factor-related protein 1 |
UniProt Protein Name: | Protein argonaute-4 |
UniProt Synonym Protein Names: | Argonaute RISC catalytic component 4; Eukaryotic translation initiation factor 2C 4 |
Protein Family: | Protein argonaute |
UniProt Gene Name: | AGO4 |
UniProt Entry Name: | AGO4_HUMAN |