バックグラウンド: | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). |
シノニム: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2), ARAP1, CENTD2 KIAA0782 |
UniProt Protein Function: | CENTD2: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAP; GAP, ARF; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; plasma membrane Molecular Function:GTPase activator activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding Biological Process: actin filament reorganization during cell cycle; negative regulation of stress fiber formation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of filopodium formation; positive regulation of GTPase activity; regulation of cell motility; regulation of cell shape; regulation of small GTPase mediated signal transduction |
NCBI Summary: | The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
UniProt Code: | Q96P48 |
NCBI GenInfo Identifier: | 226694321 |
NCBI Gene ID: | 116985 |
NCBI Accession: | Q96P48.3 |
UniProt Secondary Accession: | Q96P48,O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6 Q96L71, A3KLL7, B2RTS2, |
UniProt Related Accession: | Q96P48 |
Molecular Weight: | 162kDa |
NCBI Full Name: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 |
NCBI Synonym Full Names: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
NCBI Official Symbol: | ARAP1 |
NCBI Official Synonym Symbols: | CENTD2 |
NCBI Protein Information: | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 |
UniProt Protein Name: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 |
UniProt Synonym Protein Names: | Centaurin-delta-2; Cnt-d2 |
Protein Family: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein |
UniProt Gene Name: | ARAP1 |