APOC2 Antibody, Biotin conjugated (PACO63942)
- SKU:
- PACO63942
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | APOC2 Antibody, Biotin conjugated (PACO63942) |
抗体コード: | PACO63942 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Peptide sequence from Human Apolipoprotein C-II protein (20-38AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. |
シノニム: | Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) [Cleaved into: Proapolipoprotein C-II (ProapoC-II)], APOC2, APC2 |
UniProt Protein Function: | APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: chylomicron; early endosome; extracellular region; extracellular space Molecular Function:lipase inhibitor activity; lipid binding; phospholipase activator activity; phospholipase binding; protein homodimerization activity Biological Process: cholesterol efflux; cholesterol homeostasis; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; retinoid metabolic process; reverse cholesterol transport Disease: Apolipoprotein C-ii Deficiency |
NCBI Summary: | This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | P02655 |
NCBI GenInfo Identifier: | 114022 |
NCBI Gene ID: | 344 |
NCBI Accession: | P02655.1 |
UniProt Secondary Accession: | P02655,Q9BS39, Q9UDE3, Q9UNK3, C0JYY4, |
UniProt Related Accession: | P02655 |
Molecular Weight: | 11,284 Da |
NCBI Full Name: | Apolipoprotein C-II |
NCBI Synonym Full Names: | apolipoprotein C2 |
NCBI Official Symbol: | APOC2 |
NCBI Official Synonym Symbols: | APO-CII; APOC-II |
NCBI Protein Information: | apolipoprotein C-II |
UniProt Protein Name: | Apolipoprotein C-II |
UniProt Synonym Protein Names: | Apolipoprotein C2 |
Protein Family: | Apolipoprotein |
UniProt Gene Name: | APOC2 |
UniProt Entry Name: | APOC2_HUMAN |