APOBEC3D Antibody, FITC conjugated (PACO55236)
- SKU:
- PACO55236
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | APOBEC3D Antibody, FITC conjugated (PACO55236) |
抗体コード: | PACO55236 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DNA dC->dU-editing enzyme APOBEC-3D protein (250-371AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. |
シノニム: | DNA dC->dU-editing enzyme APOBEC-3D (A3D) (EC 3.5.4), APOBEC3D |
UniProt Protein Function: | APOBEC3D: Probable DNA cytidine deaminase involved in foreign DNA clearance. May provide cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. Belongs to the cytidine and deoxycytidylate deaminase family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.5.4.- Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm Molecular Function:zinc ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Biological Process: negative regulation of retroviral genome replication; innate immune response; defense response to virus |
UniProt Code: | Q96AK3 |
NCBI GenInfo Identifier: | 48474596 |
NCBI Gene ID: | |
NCBI Accession: | Q96AK3.1 |
UniProt Secondary Accession: | Q96AK3,Q5JZ91, Q7Z2N2, Q7Z2N5, Q7Z2N6, |
Molecular Weight: | 46598 |
NCBI Full Name: | DNA dC-> |
UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3D |
Protein Family: | DNA dC->dU-editing enzyme |
UniProt Gene Name: | APOBEC3D |
UniProt Entry Name: | ABC3D_HUMAN |