UniProt Protein Function: | APOBEC3C: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.5.4.-; RNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm; nucleus Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; protein binding; zinc ion binding Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication; viral reproduction |
NCBI Summary: | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NRW3 |
NCBI GenInfo Identifier: | 48474983 |
NCBI Gene ID: | 27350 |
NCBI Accession: | Q9NRW3.2 |
UniProt Secondary Accession: | Q9NRW3,Q5JZ92, Q7Z2N7, Q96F12, B2R884, |
UniProt Related Accession: | Q9NRW3 |
Molecular Weight: | 22,826 Da |
NCBI Full Name: | DNA dC-> |
NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C |
NCBI Official Symbol: | APOBEC3C |
NCBI Official Synonym Symbols: | A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3 |
NCBI Protein Information: | DNA dC->dU-editing enzyme APOBEC-3C |
UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3C |
UniProt Synonym Protein Names: | APOBEC1-like; Phorbolin I |
Protein Family: | DNA dC->dU-editing enzyme |
UniProt Gene Name: | APOBEC3C |
UniProt Entry Name: | ABC3C_HUMAN |