APCDD1 Antibody, HRP conjugated (PACO63444)
- SKU:
- PACO63444
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | APCDD1 Antibody, HRP conjugated (PACO63444) |
抗体コード: | PACO63444 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein APCDD1 protein (22-288AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. |
シノニム: | Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein), APCDD1, DRAPC1 |
UniProt Protein Function: | APCDD1: a single-pass type I membrane protein. Probably plays a role in colorectal tumorigenesis. Directly activated downstream targets of the WNT/beta-catenin pathway. Transcriptional target of beta-catenin/T-cell (Tcf) factor and may enhance cellular proliferation of tumor cells. Down-regulated by wild-type the adenomatosis polyposis coli (APC) protein. Elevated in many primary colon cancer tissues.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 18p11.22Cellular Component: integral to plasma membraneMolecular Function: Wnt-protein bindingBiological Process: hair follicle development; negative regulation of Wnt receptor signaling pathwayDisease: Hypotrichosis 1 |
UniProt Protein Details: | |
NCBI Summary: | This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010] |
UniProt Code: | Q8J025 |
NCBI GenInfo Identifier: | 74728445 |
NCBI Gene ID: | 147495 |
NCBI Accession: | Q8J025.1 |
UniProt Secondary Accession: | Q8J025,Q71M25, B4DUQ0, B4DZT0 |
UniProt Related Accession: | Q8J025 |
Molecular Weight: | 58,797 Da |
NCBI Full Name: | Protein APCDD1 |
NCBI Synonym Full Names: | APC down-regulated 1 |
NCBI Official Symbol: | APCDD1 |
NCBI Official Synonym Symbols: | HHS; HTS; B7323; HYPT1; DRAPC1; FP7019 |
NCBI Protein Information: | protein APCDD1 |
UniProt Protein Name: | Protein APCDD1 |
UniProt Synonym Protein Names: | Adenomatosis polyposis coli down-regulated 1 protein |
Protein Family: | |
UniProt Gene Name: | APCDD1 |
UniProt Entry Name: | APCD1_HUMAN |