APBA2 Antibody (PACO19117)
- SKU:
- PACO19117
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | APBA2 Antibody (PACO19117) |
抗体コード: | PACO19117 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | Synthetic peptide of human APBA2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19117(APBA2 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19117(APBA2 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A β peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. |
シノニム: | amyloid β (A4) precursor protein-binding, family A, member 2 |
UniProt Protein Function: | APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 15q11-q12 Molecular Function:protein binding Biological Process: nervous system development |
NCBI Summary: | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99767 |
NCBI GenInfo Identifier: | 6226950 |
NCBI Gene ID: | 321 |
NCBI Accession: | Q99767.3 |
UniProt Secondary Accession: | Q99767,O60571, Q5XKC0, E9PGI4, |
UniProt Related Accession: | Q99767 |
Molecular Weight: | 81,129 Da |
NCBI Full Name: | Amyloid beta A4 protein-binding family A member 2 |
NCBI Synonym Full Names: | amyloid beta precursor protein binding family A member 2 |
NCBI Official Symbol: | APBA2 |
NCBI Official Synonym Symbols: | X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091 |
NCBI Protein Information: | amyloid beta A4 precursor protein-binding family A member 2 |
UniProt Protein Name: | Amyloid beta A4 precursor protein-binding family A member 2 |
UniProt Synonym Protein Names: | Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2 |
Protein Family: | Amyloid beta A4 precursor protein-binding family |
UniProt Gene Name: | APBA2 |
UniProt Entry Name: | APBA2_HUMAN |