Anti-Zyxin Antibody (CAB2298)
- SKU:
- CAB2298
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ESP-2
- Synonyms:
- HED-2
Frequently bought together:
Description
| 抗体名: | Zyxin Rabbit mAb |
| 抗体コード: | CAB2298 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | ESP-2, HED-2 |
| 申し込み: | WB, IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Zyxin |
| 申し込み: | WB, IF |
| 推奨される希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, Mouse lung |
| 免疫原: | A synthesized peptide derived from human Zyxin |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 7791 |
| Uniprot: | Q15942 |
| セルラーロケーション: | Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion |
| 計算された分子量: | 78kDa |
| 観察された分子量: | 78kDa |
| UniProt Protein Function: | Zyxin: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 7q32 Cellular Component: focal adhesion; cell-cell adherens junction; integral to plasma membrane; cytoplasm; stress fiber; plasma membrane; nucleus Molecular Function:protein binding; zinc ion binding Biological Process: integrin-mediated signaling pathway; cell-cell signaling; viral reproduction; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion; regulation of inflammatory response; stress fiber formation; signal transduction; cell adhesion |
| NCBI Summary: | Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15942 |
| NCBI GenInfo Identifier: | 2497677 |
| NCBI Gene ID: | 7791 |
| NCBI Accession: | Q15942.1 |
| UniProt Secondary Accession: | Q15942,Q6I9S4, A4D2G6, B4DQX7, |
| UniProt Related Accession: | Q15942 |
| Molecular Weight: | 572 |
| NCBI Full Name: | Zyxin |
| NCBI Synonym Full Names: | zyxin |
| NCBI Official Symbol: | ZYX |
| NCBI Official Synonym Symbols: | ESP-2; HED-2 |
| NCBI Protein Information: | zyxin; zyxin-2 |
| UniProt Protein Name: | Zyxin |
| UniProt Synonym Protein Names: | Zyxin-2 |
| Protein Family: | Zyxin |
| UniProt Gene Name: | ZYX |
| UniProt Entry Name: | ZYX_HUMAN |