Anti-ZIP8 Antibody (CAB10395)
- SKU:
- CAB10395
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ZIP8 Antibody |
| 抗体コード: | CAB10395 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human ZIP8 (NP_071437.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HL-60, NCI-H460, HeLa, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human ZIP8 (NP_071437.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QLIP EAFG FDPK VDSY VEKA VAVF GGFY LLFF FERM LKML LKTY GQNG HTHF GNDN FGPQ EKTH QPKA LPAI NGVT CYAN PAVT EANG HIHF DNVS VVSL QDGK KEPS SCTC LKGP KLSE I |
| 遺伝子ID: | 64116 |
| Uniprot: | Q9C0K1 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 43kDa/48kDa/49kDa |
| 観察された分子量: | 50kDa |
| 同義語: | SLC39A8, BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8 |
| バックグラウンド: | This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
| UniProt Protein Function: | SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 4q24 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:zinc ion transmembrane transporter activity Biological Process: cellular zinc ion homeostasis; zinc ion transport Disease: Congenital Disorder Of Glycosylation, Type Iin |
| NCBI Summary: | This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9C0K1 |
| NCBI GenInfo Identifier: | 74733496 |
| NCBI Gene ID: | 64116 |
| NCBI Accession: | Q9C0K1.1 |
| UniProt Secondary Accession: | Q9C0K1,Q96SM9, Q9BVC0, Q9NSA4, B4E2H3, |
| UniProt Related Accession: | Q9C0K1 |
| Molecular Weight: | |
| NCBI Full Name: | Zinc transporter ZIP8 |
| NCBI Synonym Full Names: | solute carrier family 39 member 8 |
| NCBI Official Symbol: | SLC39A8 |
| NCBI Official Synonym Symbols: | ZIP8; CDG2N; PP3105; BIGM103; LZT-Hs6 |
| NCBI Protein Information: | zinc transporter ZIP8 |
| UniProt Protein Name: | Zinc transporter ZIP8 |
| UniProt Synonym Protein Names: | BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8; ZIP-8 |
| Protein Family: | Zinc transporter |
| UniProt Gene Name: | SLC39A8 |
 | Western blot analysis of extracts of various cell lines, using ZIP8 antibody (CAB10395) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using ZIP8 Rabbit pAb (CAB10395) at dilution of 1:100. Blue: DAPI for nuclear staining. |
View AllClose