Anti-ZIC1 Antibody (CAB19558)

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SKU:
CAB19558
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CRS6
Synonyms:
ZIC
Synonyms:
ZNF201
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Description

抗体名:ZIC1 Rabbit mAb
抗体コード:CAB19558
サイズ:20uL, 50uL, 100uL
同義語:CRS6, ZIC, ZNF201
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human ZIC1
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:C6, SH-SY5Y
免疫原:A synthesized peptide derived from human ZIC1
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:7545
Uniprot:Q15915
計算された分子量:48kDa
観察された分子量:48KDa
UniProt Protein Function:ZIC1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. Belongs to the GLI C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: nucleoplasm; nucleus

Molecular Function:transcription factor activity

Biological Process: brain development; inner ear morphogenesis; pattern specification process; positive regulation of protein import into nucleus; positive regulation of transcription, DNA-dependent; regulation of smoothened signaling pathway

Disease: Craniosynostosis 6

NCBI Summary:This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q15915
NCBI GenInfo Identifier:209572702
NCBI Gene ID:7545
NCBI Accession:Q15915.2
UniProt Secondary Accession:Q15915,Q2M3N1,
UniProt Related Accession:Q15915
Molecular Weight:48,309 Da
NCBI Full Name:Zinc finger protein ZIC 1
NCBI Synonym Full Names:Zic family member 1
NCBI Official Symbol:ZIC1  
NCBI Official Synonym Symbols:ZIC; CRS6; ZNF201  
NCBI Protein Information:zinc finger protein ZIC 1
UniProt Protein Name:Zinc finger protein ZIC 1
UniProt Synonym Protein Names:Zinc finger protein 201; Zinc finger protein of the cerebellum 1
Protein Family:Zinc finger protein
UniProt Gene Name:ZIC1  
UniProt Entry Name:ZIC1_HUMAN
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