Anti-ZC3HAV1 Antibody (CAB9219)
- SKU:
- CAB9219
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-ZC3HAV1 Antibody |
| 抗体コード: | CAB9219 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human ZC3HAV1 (NP_078901.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, LO2, OVCAR3, Mouse lung, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-400 of human ZC3HAV1 (NP_078901.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CKSY KGEG RQQI CNQQ PPCS RLHI CDHF TRGN CRFP NCLR SHNL MDRK VLAI MREH GLNP DVVQ NIQD ICNS KHMQ KNPP GPRA PSSH RRNM AYRA RSKS RDRF FQGS QEFL ASAS ASAE RSCT PSPD QISH RASL EDAP VDDL TRKF TYLG SQDR ARPP SGSS KATD LGGT SQAG TSQR FLEN GSQE DLLH GNPG STYL ASNS TSAP NWKS LTSW TNDQ GARR KTVF SPTL PAAR SSLG SLQT PEAV TTR |
| 遺伝子ID: | 56829 |
| Uniprot: | Q7Z2W4 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 18kDa/42kDa/67kDa/77kDa/101kDa |
| 観察された分子量: | 101kDa |
| 同義語: | ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 |
| バックグラウンド: | This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. |
| UniProt Protein Function: | ZAP: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; RNA-binding Chromosomal Location of Human Ortholog: 7q34 Cellular Component: Golgi apparatus; cytoplasm; nucleus Molecular Function:protein binding; metal ion binding; NAD+ ADP-ribosyltransferase activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral genome replication; metabolic process; response to virus; positive regulation of interferon-beta production; innate immune response; defense response to virus; positive regulation of interferon-alpha production |
| NCBI Summary: | This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z2W4 |
| NCBI GenInfo Identifier: | 27477138 |
| NCBI Gene ID: | 56829 |
| NCBI Accession: | NP_078901 |
| UniProt Related Accession: | Q7Z2W4 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger CCCH-type antiviral protein 1 isoform 2 |
| NCBI Synonym Full Names: | zinc finger CCCH-type containing, antiviral 1 |
| NCBI Official Symbol: | ZC3HAV1 |
| NCBI Official Synonym Symbols: | ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2 |
| NCBI Protein Information: | zinc finger CCCH-type antiviral protein 1 |
| UniProt Protein Name: | Zinc finger CCCH-type antiviral protein 1 |
| UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP |
| UniProt Gene Name: | ZC3HAV1 |
| UniProt Entry Name: | ZCCHV_HUMAN |
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