| UniProt Protein Function: | MCPIP1: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Belongs to the ZC3H12 family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.-.- Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: cytoplasm; cytoskeleton; nucleoplasm; nucleus; plasma membrane; rough endoplasmic reticulum Molecular Function:chromatin binding; DNA binding; endoribonuclease activity; exoribonuclease activity; miRNA binding; mRNA 3'-UTR binding; mRNA binding; protein binding; ribonuclease activity; ribosome binding; RNA binding Biological Process: cellular response to glucose starvation; inhibition of NF-kappaB transcription factor; mRNA catabolic process, endonucleolytic cleavage-dependent decay; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta secretion; negative regulation of interleukin-6 production; negative regulation of macrophage activation; negative regulation of NF-kappaB import into nucleus; negative regulation of nitric oxide biosynthetic process; negative regulation of protein amino acid phosphorylation; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of defense response to virus by host; positive regulation of fat cell differentiation; positive regulation of protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; protein oligomerization; regulation of gene expression |
| NCBI Summary: | ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q5D1E8 |
| NCBI GenInfo Identifier: | 190479827 |
| NCBI Gene ID: | 80149 |
| NCBI Accession: | Q5D1E8.1 |
| UniProt Secondary Accession: | Q5D1E8,Q6I9Z1, Q9H5P1, D3DPT0, |
| UniProt Related Accession: | Q5D1E8 |
| Molecular Weight: | 65,699 Da |
| NCBI Full Name: | Bifunctional endoribonuclease and deubiquitinase ZC3H12A |
| NCBI Synonym Full Names: | zinc finger CCCH-type containing 12A |
| NCBI Official Symbol: | ZC3H12A |
| NCBI Official Synonym Symbols: | MCPIP; MCPIP1; dJ423B22.1 |
| NCBI Protein Information: | bifunctional endoribonuclease and deubiquitinase ZC3H12A |
| UniProt Protein Name: | Bifunctional endoribonuclease and deubiquitinase ZC3H12A |
| UniProt Synonym Protein Names: | Monocyte chemotactic protein-induced protein 1 |
| Protein Family: | Ribonuclease |
| UniProt Gene Name: | ZC3H12A |
| UniProt Entry Name: | ZC12A_HUMAN |
