Anti-YOD1 Antibody (CAB13270)
- SKU:
- CAB13270
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-YOD1 Antibody |
| 抗体コード: | CAB13270 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human YOD1 (NP_061036.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human YOD1 (NP_061036.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MFGP AKGR HFGV HPAP GFPG GVSQ QAAG TKAG PAGA WPVG SRTD TMWR LRCK AKDG THVL QGLS SRTR VREL QGQI AAIT GIAP GGQR ILVG YPPE CLDL SNGD TILE DLPI QSGD MLII EEDQ TRPR SSPA FTKR GASS YVRE TLPV LTRT VVPA DNSC LFTS VYYV VEGG VLNP ACAP EMRR LIAQ IVAS DPDF YSEA ILGK TNQE YCDW IKRD DTWG GAIE ISIL SKFY QCEI CVVD TQTV RIDR FGED AGYT KRVL LIYD GIHY DPLQ RNFP DPDT PPLT IFSS NDDI VLVQ ALEL ADEA RRRR QFTD VNRF TLRC MVCQ KGLT GQAE AREH AKET GHTN FGEV |
| 遺伝子ID: | 55432 |
| Uniprot: | Q5VVQ6 |
| セルラーロケーション: | |
| 計算された分子量: | 33kDa/38kDa |
| 観察された分子量: | 41kDa |
| 同義語: | YOD1, DUBA8, OTUD2, PRO0907 |
| バックグラウンド: | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | YOD1: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di- ubiquitin. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - unsaturated fatty acid biosynthesis; Protease; EC 3.4.19.12; Ubiquitin-specific protease; C2H2-type zinc finger protein; Secondary Metabolites Metabolism - limonene and pinene degradation Chromosomal Location of Human Ortholog: 1q32.2 Molecular Function:protein binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity Biological Process: ER-associated protein catabolic process; unfolded protein response |
| NCBI Summary: | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q5VVQ6 |
| NCBI GenInfo Identifier: | 74747276 |
| NCBI Gene ID: | 55432 |
| NCBI Accession: | Q5VVQ6.1 |
| UniProt Secondary Accession: | Q5VVQ6,Q5VVQ5, Q6ZRS6, Q86T63, Q9P1L8, B2RNX3, |
| UniProt Related Accession: | Q5VVQ6 |
| Molecular Weight: | 33,979 Da |
| NCBI Full Name: | Ubiquitin thioesterase OTU1 |
| NCBI Synonym Full Names: | YOD1 deubiquitinase |
| NCBI Official Symbol: | YOD1 |
| NCBI Official Synonym Symbols: | DUBA8; OTUD2; PRO0907 |
| NCBI Protein Information: | ubiquitin thioesterase OTU1 |
| UniProt Protein Name: | Ubiquitin thioesterase OTU1 |
| UniProt Synonym Protein Names: | DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2 |
| UniProt Gene Name: | YOD1 |
| UniProt Entry Name: | OTU1_HUMAN |
 | Western blot analysis of extracts of mouse brain, using YOD1 antibody (CAB13270) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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