Anti-XPO7 Antibody (CAB16108)
- SKU:
- CAB16108
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-XPO7 Antibody |
| 抗体コード: | CAB16108 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human XPO7 (NP_055839.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, HT-29, Mouse testis, Mouse spleen, Mouse liver, Rat testis |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human XPO7 (NP_055839.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SMSR PLLG LILL NEKY FSDL RNSI VNSQ PPEK QQAM HLCF ENLM EGIE RNLL TKNR DRFT QNLS AFRR EVND SMKN STYG VNSN DMMS |
| 遺伝子ID: | 23039 |
| Uniprot: | Q9UIA9 |
| セルラーロケーション: | Cytoplasm, Nucleus, nuclear pore complex |
| 計算された分子量: | 123kDa |
| 観察された分子量: | 124kDa |
| 同義語: | XPO7, EXP7, RANBP16 |
| バックグラウンド: | The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors. |
| UniProt Protein Function: | Exportin-7: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family. |
| UniProt Protein Details: | Protein type:Karyopherin; Nuclear import; Nuclear export Chromosomal Location of Human Ortholog: 8p21 Cellular Component: cytoplasm; nuclear pore; nucleus Molecular Function:nuclear export signal receptor activity; Ran GTPase binding Biological Process: mRNA transport; protein export from nucleus |
| NCBI Summary: | The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q9UIA9 |
| NCBI GenInfo Identifier: | 40225692 |
| NCBI Gene ID: | 23039 |
| NCBI Accession: | AAH14219.1 |
| UniProt Secondary Accession: | Q9UIA9,O94846, Q6PJK9, Q8NEK7, |
| UniProt Related Accession: | Q9UIA9 |
| Molecular Weight: | 123,907 Da |
| NCBI Full Name: | XPO7 protein, partial |
| NCBI Synonym Full Names: | exportin 7 |
| NCBI Official Symbol: | XPO7 |
| NCBI Official Synonym Symbols: | EXP7; RANBP16 |
| NCBI Protein Information: | exportin-7; RAN binding protein 16 |
| UniProt Protein Name: | Exportin-7 |
| UniProt Synonym Protein Names: | Ran-binding protein 16 |
| Protein Family: | Exportin |
| UniProt Gene Name: | XPO7 |
| UniProt Entry Name: | XPO7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using XPO7 antibody (CAB16108) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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