Anti-XPA Antibody (CAB1626)[KO Validated]
- SKU:
- CAB1626
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-XPA Antibody [KO Validated] |
抗体コード: | CAB1626 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human XPA (NP_000371.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, Jurkat, K-562, Mouse liver, Mouse kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human XPA (NP_000371.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAA DGAL PEAA ALEQ PAEL PASV RASI ERKR QRAL MLRQ ARLA ARPY SATA AAAT GGMA NVKA APKI IDTG GGFI LEEE EEEE QKIG KVVH QPGP VMEF DYVI CEEC GKEF MDSY LMNH FDLP TCDN CRDA DDKH KLIT KTEA KQEY LLKD CDLE KREP PLKF IVKK NPHH SQWG DMKL YLKL QIVK RSLE VWGS QEAL EEAK EVRQ ENRE KMKQ KKFD KKVK ELRR AVRS SVWK RETI VHQH EYGP EENL EDDM YRKT CTMC GHEL TYEK M |
遺伝子ID: | 7507 |
Uniprot: | P23025 |
セルラーロケーション: | Nucleus |
計算された分子量: | 31kDa |
観察された分子量: | 37kDa |
同義語: | XPA, XP1, XPAC |
バックグラウンド: | This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | XPA: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: cytoplasm; DNA replication factor A complex; Golgi apparatus; intercellular bridge; nucleoplasm; nucleus Molecular Function:damaged DNA binding; protein binding; protein domain specific binding; protein homodimerization activity Biological Process: base-excision repair; DNA repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; transcription-coupled nucleotide-excision repair Disease: Xeroderma Pigmentosum, Complementation Group A |
NCBI Summary: | This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
UniProt Code: | P23025 |
NCBI GenInfo Identifier: | 139816 |
NCBI Gene ID: | 7507 |
NCBI Accession: | P23025.1 |
UniProt Secondary Accession: | P23025,Q5T1U9, Q6LCW7, Q6LD02, |
UniProt Related Accession: | P23025 |
Molecular Weight: | 31,368 Da |
NCBI Full Name: | DNA repair protein complementing XP-A cells |
NCBI Synonym Full Names: | XPA, DNA damage recognition and repair factor |
NCBI Official Symbol: | XPA |
NCBI Official Synonym Symbols: | XP1; XPAC |
NCBI Protein Information: | DNA repair protein complementing XP-A cells |
UniProt Protein Name: | DNA repair protein complementing XP-A cells |
UniProt Synonym Protein Names: | Xeroderma pigmentosum group A-complementing protein |
Protein Family: | DNA repair protein |
UniProt Gene Name: | XPA |
UniProt Entry Name: | XPA_HUMAN |