Anti-XIAP Antibody (CAB16754)
- SKU:
- CAB16754
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-XIAP Antibody |
| 抗体コード: | CAB16754 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTFN SFEG SKTC VPAD INKE EEFV EEFN RLKT FANF PSGS PVSA STLA RAGF LYTG EGDT VRCF SCHA AVDR WQYG DSAV GRHR KVSP NCRF INGF YLEN SATQ STNS GIQN GQYK VENY LGSR DHFA LDRP SETH ADYL LRTG QVVD ISDT IYPR NPAM YSEE ARLK SFQN WPDY AHLT PREL ASAG LYYT GIGD QVQC |
| 遺伝子ID: | 331 |
| Uniprot: | P98170 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 56kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 |
| バックグラウンド: | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |
| UniProt Protein Function: | XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: Xq25 Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; nucleus; cytosol Molecular Function:protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activity Biological Process: Wnt receptor signaling pathway; positive regulation of protein ubiquitination; apoptosis; regulation of inflammatory response; regulation of BMP signaling pathway; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; negative regulation of apoptosis; regulation of innate immune response Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2 |
| NCBI Summary: | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P98170 |
| NCBI GenInfo Identifier: | 12643387 |
| NCBI Gene ID: | 331 |
| NCBI Accession: | P98170.2 |
| UniProt Secondary Accession: | P98170,Q9NQ14, D3DTF2, |
| UniProt Related Accession: | P98170 |
| Molecular Weight: | 497 |
| NCBI Full Name: | E3 ubiquitin-protein ligase XIAP |
| NCBI Synonym Full Names: | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | XIAP |
| NCBI Official Synonym Symbols: | API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase XIAP |
| UniProt Synonym Protein Names: | Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP |
| Protein Family: | XIAP-associated factor |
| UniProt Gene Name: | XIAP |
| UniProt Entry Name: | XIAP_HUMAN |
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