Anti-XDH Antibody (CAB13052)
- SKU:
- CAB13052
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-XDH Antibody |
| 抗体コード: | CAB13052 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human XDH (NP_000370.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human XDH (NP_000370.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTAD KLVF FVNG RKVV EKNA DPET TLLA YLRR KLGL SGTK LGCG EGGC GACT VMLS KYDR LQNK IVHF SANA CLAP ICSL HHVA VTTV EGIG STKT RLHP VQER IAKS HGSQ CGFC TPGI VMSM YTLL RNQP EPTM EEIE NAFQ GNLC RCTG YRPI LQGF RTFA RDGG CCGG DGNN PNCC MNQK KDHS VSLS PSLF KPEE FTPL DPTQ EPIF PPEL LRLK DTPR KQLR FEGE RVTW IQAS TLKE LLDL KAQH PDAK LVVG NTEI GIEM KFKN MLFP MIVC |
| 遺伝子ID: | 7498 |
| Uniprot: | P47989 |
| セルラーロケーション: | Cytoplasm, Peroxisome, Secreted |
| 計算された分子量: | 146kDa |
| 観察された分子量: | 146kDa |
| 同義語: | XDH, XAN1, XO, XOR |
| バックグラウンド: | Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. |
| UniProt Protein Function: | XDH: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Defects in XDH are the cause of xanthinuria type 1 (XU1). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. Belongs to the xanthine dehydrogenase family. |
| UniProt Protein Details: | Protein type:EC 1.17.1.4; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine; EC 1.17.3.2; Oxidoreductase Chromosomal Location of Human Ortholog: 2p23.1 Cellular Component: cytosol; extracellular space Molecular Function:2 iron, 2 sulfur cluster binding; FAD binding; molybdopterin cofactor binding; oxidoreductase activity, acting on the aldehyde or oxo group of donors; protein homodimerization activity; xanthine dehydrogenase activity; xanthine oxidase activity Biological Process: caspase activation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; purine nucleotide catabolic process; xanthine catabolic process Disease: Xanthinuria, Type I |
| NCBI Summary: | Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P47989 |
| NCBI GenInfo Identifier: | 2506326 |
| NCBI Gene ID: | 7498 |
| NCBI Accession: | P47989.4 |
| UniProt Secondary Accession: | P47989,Q16681, Q16712, Q4PJ16, |
| UniProt Related Accession: | P47989 |
| Molecular Weight: | 146,424 Da |
| NCBI Full Name: | Xanthine dehydrogenase/oxidase |
| NCBI Synonym Full Names: | xanthine dehydrogenase |
| NCBI Official Symbol: | XDH |
| NCBI Official Synonym Symbols: | XO; XOR |
| NCBI Protein Information: | xanthine dehydrogenase/oxidase |
| UniProt Protein Name: | Xanthine dehydrogenase/oxidase |
| UniProt Synonym Protein Names: | Xanthine oxidoreductase; XOR |
| Protein Family: | Xanthine dehydrogenase |
| UniProt Gene Name: | XDH |
| UniProt Entry Name: | XDH_HUMAN |
 | Western blot analysis of extracts of mouse liver, using XDH antibody (CAB13052) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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