Anti-WWC1 Antibody (CAB17110)

(No reviews yet) Write a Review
SKU:
CAB17110
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
€0.00
Frequently bought together:

Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-WWC1 Antibody
抗体コード:CAB17110
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthetic peptide corresponding to a sequence within amino acids 950-1050 of human WWC1 (NP_001155133.1).
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, Mouse lung, Mouse brain, Rat brain
免疫原:A synthetic peptide corresponding to a sequence within amino acids 950-1050 of human WWC1 (NP_001155133.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:STLS KKPP FVRN SLER RSVR MKRP SPPP QPSS VKSL RSER LIRT SLDL ELDL QATR TWHS QLTQ EISV LKEL KEQL EQAK SHGE KELP QWLR EDER FRLL L
遺伝子ID:23286
Uniprot:Q8IX03
セルラーロケーション:
計算された分子量:
観察された分子量:125kDa
Anti-WWC1 Antibody (CAB17110)Western blot - WWC1 Rabbit pAb (CAB17110)
同義語:WWC1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
バックグラウンド:The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:KIBRA: a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL. Two human isoforms have been described.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function:kinase binding; protein binding; protein complex scaffold; transcription coactivator activity

Biological Process: cell migration; establishment of cell polarity; negative regulation of organ growth; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; regulation of intracellular transport

Disease: Memory Quantitative Trait Locus

NCBI Summary:The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:Q8IX03
NCBI GenInfo Identifier:74714457
NCBI Gene ID:23286
NCBI Accession:Q8IX03.1
UniProt Secondary Accession:Q8IX03,O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29 B4DK05,
UniProt Related Accession:Q8IX03
Molecular Weight:125,905 Da
NCBI Full Name:Protein KIBRA
NCBI Synonym Full Names:WW and C2 domain containing 1
NCBI Official Symbol:WWC1  
NCBI Official Synonym Symbols:KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168  
NCBI Protein Information:protein KIBRA
UniProt Protein Name:Protein KIBRA
UniProt Synonym Protein Names:HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1
UniProt Gene Name:WWC1  
UniProt Entry Name:KIBRA_HUMAN
View AllClose

View AllClose

Related Products