Anti-WDR77 Antibody (CAB7134)
- SKU:
- CAB7134
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-WDR77 Antibody |
| 抗体コード: | CAB7134 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human WDR77 (NP_077007.1). |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human WDR77 (NP_077007.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MRKE TPPP LVPP AARE WNLP PNAP ACME RQLE AARY RSDG ALLL GASS LSGR CWAG SLWL FKDP CAAP NEGF CSAG VQTE AGVA DLTW VGER GILV ASDS GAVE LWEL DENE TLIV SKFC KYEH DDIV STVS VLSS GTQA VSGS KDIC IKVW DLAQ QVVL SSYR AHAA QVTC VAAS PHKD SVFL SCSE DNRI LLWD TRCP KPAS QIGC SAPG YLPT SLAW HPQQ SEVF VFGD ENGT VSLV DTKS TSCV LSSA VHSQ CVTG |
| 遺伝子ID: | 79084 |
| Uniprot: | Q9BQA1 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 29kDa/36kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | WDR77, HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50 |
| バックグラウンド: | The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Adaptor/scaffold; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; cytosol; nucleus Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; establishment and/or maintenance of chromatin architecture; positive regulation of cell proliferation; gene expression |
| NCBI Summary: | WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BQA1 |
| NCBI GenInfo Identifier: | 32171507 |
| NCBI Gene ID: | 79084 |
| NCBI Accession: | Q9BQA1.1 |
| UniProt Secondary Accession: | Q9BQA1,Q3LID2, Q53FU2, Q6JZZ5, Q96GK4, Q9BWY3, B3KMW6 B4DP38, |
| UniProt Related Accession: | Q9BQA1 |
| Molecular Weight: | 342 |
| NCBI Full Name: | Methylosome protein 50 |
| NCBI Synonym Full Names: | WD repeat domain 77 |
| NCBI Official Symbol: | WDR77 |
| NCBI Official Synonym Symbols: | p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50 |
| NCBI Protein Information: | methylosome protein 50; androgen receptor cofactor p44; WD repeat-containing protein 77 |
| UniProt Protein Name: | Methylosome protein 50 |
| UniProt Synonym Protein Names: | Androgen receptor cofactor p44; WD repeat-containing protein 77; p44/Mep50 |
| Protein Family: | Methylosome protein |
| UniProt Gene Name: | WDR77 |
| UniProt Entry Name: | MEP50_HUMAN |
 | Immunohistochemistry of paraffin-embedded human prostate using WDR77 antibody (CAB7134) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using WDR77 antibody (CAB7134) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of A-549 cells using WDR77 antibody (CAB7134). Blue: DAPI for nuclear staining. |
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