Anti-WDR35 Antibody (CAB12824)
- SKU:
- CAB12824
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-WDR35 Antibody |
| 抗体コード: | CAB12824 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 871-1170 of human WDR35 (NP_065830.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:1000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 871-1170 of human WDR35 (NP_065830.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CSQP KAAV DTCV HLNQ WNKA VELA KNHS MKEI GSLL ARYA SHLL EKNK TLDA IELY RKAN YFFD AAKL MFKI ADEE AKKG SKPL RVKK LYVL SALL IEQY HEQM KNAQ RGKV KGKS SEAT SALA GLLE EEVL STTD RFTD NAWR GAEA YHFF ILAQ RQLY EGCV DTAL KTAL HLKD YEDI IPPV EIYS LLAL CACA SRAF GTCS KAFI KLKS LETL SSEQ KQQY EDLA LEIF TKHT SKDN RKPE LDSL MEGG EGKL PTCV ATGS PITE YQFW MCSV CKHG VLAQ EISH YSFC PLCH SPVG |
| 遺伝子ID: | 57539 |
| Uniprot: | Q9P2L0 |
| セルラーロケーション: | Cytoplasm, centrosome, cilium axoneme, cilium basal body, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 132kDa/133kDa |
| 観察された分子量: | 133kDa |
| 同義語: | WDR35, CED2, IFT121, IFTA1, SRTD7 |
| バックグラウンド: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function. |
| UniProt Protein Function: | WDR35: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: axoneme; centrosome; cilium Molecular Function:phosphoinositide binding Disease: Cranioectodermal Dysplasia 2; Short-rib Thoracic Dysplasia 7 With Or Without Polydactyly |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9P2L0 |
| NCBI GenInfo Identifier: | 48474987 |
| NCBI Gene ID: | 57539 |
| NCBI Accession: | Q9P2L0.3 |
| UniProt Secondary Accession: | Q9P2L0,Q4ZG01, Q8NE11, B3KVI5, |
| UniProt Related Accession: | Q9P2L0 |
| Molecular Weight: | 134kDa |
| NCBI Full Name: | WD repeat-containing protein 35 |
| NCBI Synonym Full Names: | WD repeat domain 35 |
| NCBI Official Symbol: | WDR35 |
| NCBI Official Synonym Symbols: | CED2; IFTA1; SRTD7; IFT121 |
| NCBI Protein Information: | WD repeat-containing protein 35 |
| UniProt Protein Name: | WD repeat-containing protein 35 |
| UniProt Synonym Protein Names: | Intraflagellar transport protein 121 homolog |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR35 |
 | Western blot analysis of extracts of LO2 cells, using WDR35 antibody (CAB12824) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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