Anti-WDR11 Antibody (CAB10590)
- SKU:
- CAB10590
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-WDR11 Antibody |
| 抗体コード: | CAB10590 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | DU145, HL-60, HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | YFQK FQLE RVNL QEVK RSTY DHTR KCTD QLLL LGQT DRAV QLLL ETSA DNQH YYCD SLKA CLVT TVTS SGPS QSTI KLVA TNMI ANGK LAEG VQLL CLID KAAD ACRY LQTY GEWN RAAW LAKV RLNP EECA DVLR RWVD HLCS PQVN QKSK ALLV LLSL GCFF SVAE TLHS MRYF DRAA LFVE ACLK YGAF EVTE DTEK LITA IYAD YARS LKNL GFKQ GAVL FASK AGAA GKDL LNEL ESPK EEPI EE |
| 遺伝子ID: | 55717 |
| Uniprot: | Q9BZH6 |
| セルラーロケーション: | Cytoplasm, Membrane, Nucleus, Single-pass membrane protein |
| 計算された分子量: | 136kDa |
| 観察された分子量: | 130kDa |
| 同義語: | WDR11, BRWD2, DR11, HH14, SRI1, WDR15 |
| バックグラウンド: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. |
| UniProt Protein Function: | BRWD2: a protein with two WD40 domains. A translocation of BRWD2 with ZNF320 is found in a form of glioblastoma (t(10;19)(q26;q13.3)). |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oncoprotein Chromosomal Location of Human Ortholog: 10q26.12 Cellular Component: cytoplasm; cytosol; lysosomal membrane; membrane; microtubule cytoskeleton Molecular Function:protein binding Disease: Hypogonadotropic Hypogonadism 14 With Or Without Anosmia; Hypogonadotropic Hypogonadism 7 With Or Without Anosmia |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZH6 |
| NCBI GenInfo Identifier: | 17368715 |
| NCBI Gene ID: | 55717 |
| NCBI Accession: | Q9BZH6.1 |
| UniProt Secondary Accession: | Q9BZH6,Q5VWA1, Q9P2J6, |
| UniProt Related Accession: | Q9BZH6 |
| Molecular Weight: | 137kDa |
| NCBI Full Name: | WD repeat-containing protein 11 |
| NCBI Synonym Full Names: | WD repeat domain 11 |
| NCBI Official Symbol: | WDR11 |
| NCBI Official Synonym Symbols: | DR11; HH14; SRI1; BRWD2; WDR15 |
| NCBI Protein Information: | WD repeat-containing protein 11 |
| UniProt Protein Name: | WD repeat-containing protein 11 |
| UniProt Synonym Protein Names: | Bromodomain and WD repeat-containing protein 2; WD repeat-containing protein 15 |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR11 |
 | Western blot analysis of extracts of various cell lines, using WDR11 antibody (CAB10590) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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