Anti-VPS54 Antibody (CAB13215)

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SKU:
CAB13215
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-VPS54 Antibody
抗体コード:CAB13215
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 420-720 of human VPS54 (NP_001005739.1).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse
ポジティブサンプル:293T, Mouse kidney, Mouse lung
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 420-720 of human VPS54 (NP_001005739.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:VVKL ADQM RMLN FPQW FDLL KDIF SKFT IFLQ RVKA TLNI IHSV VLSV LDKN QRTR ELEE ISQQ KNAA KDNS LDTE VAYL IHEG MFIS DAFG EGEL TPIA VDTT SQRN ASPN SEPC SSDS VSEP ECTT DSSS SKEH TSSS AIPG GVDI MVSE DMKL TDSE LGKL ANNI QELL YSAS DICH DRAV KFLM SRAK DGFL EKLN SMEF ITLS RLME TFIL DTEQ ICGR KSTS LLGA LQSQ AIKF VNRF HEER KTKL SLLL DNER WKQA DVPA EFQD LVDS LSDG KIAL PEKK SGAT EERK PAEV L
遺伝子ID:51542
Uniprot:Q9P1Q0
セルラーロケーション:Golgi apparatus, trans-Golgi network
計算された分子量:15kDa/93kDa/109kDa/110kDa
観察された分子量:110kDa
同義語:VPS54, HCC8, PPP1R164, SLP-8p, VPS54L, WR, hVps54L
バックグラウンド:This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms
UniProt Protein Function:Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).
NCBI Summary:This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]
UniProt Code:Q9P1Q0
NCBI GenInfo Identifier:82583721
NCBI Gene ID:51542
NCBI Accession:Q9P1Q0.2
UniProt Secondary Accession:Q9P1Q0,Q5VIR5, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0
UniProt Related Accession:Q9P1Q0
Molecular Weight:15,982 Da
NCBI Full Name:Vacuolar protein sorting-associated protein 54
NCBI Synonym Full Names:VPS54, GARP complex subunit
NCBI Official Symbol:VPS54  
NCBI Official Synonym Symbols:WR; HCC8; SLP-8p; VPS54L; hVps54L; PPP1R164  
NCBI Protein Information:vacuolar protein sorting-associated protein 54
UniProt Protein Name:Vacuolar protein sorting-associated protein 54
UniProt Synonym Protein Names:Hepatocellular carcinoma protein 8; Tumor antigen HOM-HCC-8; Tumor antigen SLP-8p
UniProt Gene Name:VPS54  
UniProt Entry Name:VPS54_HUMAN
Anti-VPS54 Antibody (CAB13215)Western blot analysis of extracts of various cell lines, using VPS54 antibody (CAB13215) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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