| UniProt Protein Function: | VPREB1: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation. Belongs to the immunoglobulin superfamily. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q11.22 Cellular Component: extracellular space Biological Process: immune response; immunoglobulin production |
| NCBI Summary: | The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P12018 |
| NCBI GenInfo Identifier: | 9911096 |
| NCBI Gene ID: | 7441 |
| NCBI Accession: | P12018.2 |
| UniProt Secondary Accession: | P12018,B5MCG2, |
| UniProt Related Accession: | P12018 |
| Molecular Weight: | 16,605 Da |
| NCBI Full Name: | Immunoglobulin iota chain |
| NCBI Synonym Full Names: | pre-B lymphocyte 1 |
| NCBI Official Symbol: | VPREB1 |
| NCBI Official Synonym Symbols: | IGI; IGVPB; VPREB; CD179a |
| NCBI Protein Information: | immunoglobulin iota chain |
| UniProt Protein Name: | Immunoglobulin iota chain |
| UniProt Synonym Protein Names: | CD179 antigen-like family member A; Protein VPreB1; V(pre)B protein; VpreB protein; CD_antigen: CD179a |
| Protein Family: | Immunoglobulin |
| UniProt Gene Name: | VPREB1 |
| UniProt Entry Name: | VPREB_HUMAN |
