Anti-Versican Antibody (CAB20278)

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SKU:
CAB20278
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
WGN
Synonyms:
ERVR
Synonyms:
GHAP
Synonyms:
PG-M
Synonyms:
WGN1
Synonyms:
CSPG2
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Description

抗体名:Versican Rabbit pAb
抗体コード:CAB20278
サイズ:50uL, 100uL
同義語:WGN, ERVR, GHAP, PG-M, WGN1, CSPG2
申し込み:IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human Versican .
申し込み:IF
推奨される希釈:IF 1:50 - 1:200
反応性:Human, Mouse, Rat
免疫原:Recombinant protein of human Versican .
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:1462
Uniprot:P13611
観察された分子量:Refer to figures
UniProt Protein Function:CSPG2: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1). WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Belongs to the aggrecan/versican proteoglycan family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; lysosomal lumen; intracellular membrane-bound organelle; membrane; Golgi lumen; extracellular region

Molecular Function:protein binding; glycosaminoglycan binding; extracellular matrix structural constituent; hyaluronic acid binding; calcium ion binding; carbohydrate binding

Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; multicellular organismal development; heart development; cell recognition; pathogenesis; glial cell migration; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; osteoblast differentiation; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development

Disease: Wagner Vitreoretinopathy

NCBI Summary:This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
UniProt Code:P13611
NCBI GenInfo Identifier:21361116
NCBI Gene ID:1462
NCBI Accession:NP_004376.2
UniProt Secondary Accession:P13611,P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5
UniProt Related Accession:P13611
Molecular Weight:369,688 Da
NCBI Full Name:versican core protein isoform 1
NCBI Synonym Full Names:versican
NCBI Official Symbol:VCAN  
NCBI Official Synonym Symbols:WGN; ERVR; GHAP; PG-M; WGN1; CSPG2  
NCBI Protein Information:versican core protein
UniProt Protein Name:Versican core protein
UniProt Synonym Protein Names:Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M
UniProt Gene Name:VCAN  
UniProt Entry Name:CSPG2_HUMAN
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