Anti-VDAC2 Antibody (CAB18683)
- SKU:
- CAB18683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-VDAC2 Antibody |
| 抗体コード: | CAB18683 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VDAC2 (NP_003366.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, HepG2, HeLa, Mouse testis, Mouse kidney, Mouse brain, Rat kidney, Rat heart, Rat brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VDAC2 (NP_003366.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 7417 |
| Uniprot: | P45880 |
| セルラーロケーション: | Mitochondrion outer membrane |
| 計算された分子量: | 30kDa/31kDa/33kDa |
| 観察された分子量: | 30kDa |
 | Western blot - VDAC2 Rabbit pAb (CAB18683) |
| 同義語: | VDAC2, POR, voltage dependent anion channel 2 |
| バックグラウンド: | This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | VDAC2: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Channel, misc. Chromosomal Location of Human Ortholog: 10q22 Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; nucleus Molecular Function:protein binding; nucleotide binding; voltage-gated anion channel activity; porin activity Biological Process: negative regulation of protein polymerization; transmembrane transport; anion transport |
| NCBI Summary: | This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | P45880 |
| NCBI GenInfo Identifier: | 158518391 |
| NCBI Gene ID: | 7417 |
| NCBI Accession: | P45880.2 |
| UniProt Secondary Accession: | P45880,Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6 |
| UniProt Related Accession: | P45880 |
| Molecular Weight: | 294 |
| NCBI Full Name: | Voltage-dependent anion-selective channel protein 2 |
| NCBI Synonym Full Names: | voltage-dependent anion channel 2 |
| NCBI Official Symbol: | VDAC2 |
| NCBI Official Synonym Symbols: | POR |
| NCBI Protein Information: | voltage-dependent anion-selective channel protein 2; outer mitochondrial membrane protein porin 2 |
| UniProt Protein Name: | Voltage-dependent anion-selective channel protein 2 |
| UniProt Synonym Protein Names: | Outer mitochondrial membrane protein porin 2 |
| Protein Family: | Voltage-dependent anion-selective channel protein |
| UniProt Gene Name: | VDAC2 |
| UniProt Entry Name: | VDAC2_HUMAN |