Anti-VAC14 Antibody (CAB16782)
- SKU:
- CAB16782
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-VAC14 Antibody |
| 抗体コード: | CAB16782 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human VAC14. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human VAC14. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 55697 |
| Uniprot: | Q08AM6 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | TRX, TAX1BP2, ArPIKfyve, VAC14 |
| バックグラウンド: | This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3, 5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. |
| UniProt Protein Function: | VAC14: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Belongs to the VAC14 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: early endosome membrane; endosome membrane; Golgi membrane; late endosome membrane Molecular Function:protein binding Biological Process: phosphatidylinositol biosynthetic process |
| NCBI Summary: | The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010] |
| UniProt Code: | Q08AM6 |
| NCBI GenInfo Identifier: | 121940040 |
| NCBI Gene ID: | 55697 |
| NCBI Accession: | Q08AM6.1 |
| UniProt Secondary Accession: | Q08AM6,Q13174, Q6IA12, Q7L4Y1, Q9BW96, Q9H6V6, B3KPJ5 B3KSM8, |
| UniProt Related Accession: | Q08AM6 |
| Molecular Weight: | 24,783 Da |
| NCBI Full Name: | Protein VAC14 homolog |
| NCBI Synonym Full Names: | Vac14, PIKFYVE complex component |
| NCBI Official Symbol: | VAC14 |
| NCBI Official Synonym Symbols: | TRX; TAX1BP2; ArPIKfyve |
| NCBI Protein Information: | protein VAC14 homolog |
| UniProt Protein Name: | Protein VAC14 homolog |
| UniProt Synonym Protein Names: | Tax1-binding protein 2 |
| Protein Family: | Vacuole morphology and inheritance protein |
| UniProt Gene Name: | VAC14 |
| UniProt Entry Name: | VAC14_HUMAN |