Anti-USP10 Antibody (CAB7505)
- SKU:
- CAB7505
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| 抗体名: | Anti-USP10 Antibody |
| 抗体コード: | CAB7505 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 499-798 of human USP10 (NP_005144.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 499-798 of human USP10 (NP_005144.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FEPT YIYR LLTV NKSS LSEK GRQE DAEE YLGF ILNG LHEE MLNL KKLL SPSN EKLT ISNG PKNH SVNE EEQE EQGE GSED EWEQ VGPR NKTS VTRQ ADFV QTPI TGIF GGHI RSVV YQQS SKES ATLQ PFFT LQLD IQSD KIRT VQDA LESL VARE SVQG YTTK TKQE VEIS RRVT LEKL PPVL VLHL KRFV YEKT GGCQ KLIK NIEY PVDL EISK ELLS PGVK NKNF KCHR TYRL FAVV YHHG NSAT GGHY TTDV FQIG LNGW LRID DQTV KVIN QYQV VKPT AERT AYLL YYRR VDLL |
| 遺伝子ID: | 9100 |
| Uniprot: | Q14694 |
| セルラーロケーション: | Cytoplasm, Early endosome, Nucleus |
| 計算された分子量: | 87kDa/92kDa |
| 観察された分子量: | 110kDa |
| 同義語: | UBPO, USP10 |
| バックグラウンド: | Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. |
| UniProt Protein Function: | USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains. |
| UniProt Protein Details: | Protein type:Protease; Ubiquitin conjugating system; EC 3.4.19.12; RNA-binding; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: cytoplasm; early endosome; nucleoplasm; nucleus Molecular Function:cysteine-type endopeptidase activity; p53 binding; protein binding; ubiquitin-specific protease activity Biological Process: bypass DNA synthesis; DNA damage response, signal transduction by p53 class mediator; protein deubiquitination; regulation of autophagy |
| NCBI Summary: | Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q14694 |
| NCBI GenInfo Identifier: | 2501458 |
| NCBI Gene ID: | 9100 |
| NCBI Accession: | Q14694.2 |
| UniProt Secondary Accession: | Q14694,Q9BWG7, Q9NSL7, B2RDJ8, B4DS84, |
| UniProt Related Accession: | Q14694 |
| Molecular Weight: | 87,533 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 10 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 10 |
| NCBI Official Symbol: | USP10 |
| NCBI Official Synonym Symbols: | UBPO |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 10 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 10 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10 |
| UniProt Gene Name: | USP10 |
| UniProt Entry Name: | UBP10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using USP10 antibody (CAB7505) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using USP10 antibody (CAB7505). Blue: DAPI for nuclear staining. |
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