Anti-USF1 Antibody (CAB13560)
- SKU:
- CAB13560
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| 抗体名: | Anti-USF1 Antibody |
| 抗体コード: | CAB13560 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human USF1 (NP_009053.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human USF1 (NP_009053.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKGQ QKTA ETEE GTVQ IQEG AVAT GEDP TSVA IASI QSAA TFPD PNVK YVFR TENG GQVM YRVI QVSE GQLD GQTE GTGA ISGY PATQ SMTQ AVIQ GAFT SDDA VDTE GTAA ETHY TYFP STAV GDGA GGTT SGST AAVV TTQG SEAL LGQA TPPG TGQF FVMM SPQE VLQG GSQR SIAP RTHP YSPK SEAP RTTR DEKR RAQH NEVE RRRR DKIN NWIV QLSK IIPD CSME STKS GQSK GGIL SKAC DYIQ ELRQ SNHR LSEE LQGL DQLQ LDND VLRQ QVED LKNK NLLL RAQL RHHG LEVV IKND SN |
| 遺伝子ID: | 7391 |
| Uniprot: | P22415 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 27kDa/33kDa |
| 観察された分子量: | 41kDa |
| 同義語: | USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 |
| バックグラウンド: | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. |
| UniProt Protein Function: | USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; protein kinase binding Biological Process: transcription from RNA polymerase II promoter; lipid homeostasis; glucose metabolic process; late viral mRNA transcription; glucose homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of fibrinolysis; cellular response to insulin stimulus; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; regulation of transcription by carbon catabolites; positive regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of transcription from RNA polymerase II promoter; response to UV Disease: Hyperlipidemia, Combined, 1 |
| NCBI Summary: | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] |
| UniProt Code: | P22415 |
| NCBI GenInfo Identifier: | 137170 |
| NCBI Gene ID: | 7391 |
| NCBI Accession: | P22415.1 |
| UniProt Related Accession: | P22415 |
| Molecular Weight: | |
| NCBI Full Name: | Upstream stimulatory factor 1 |
| NCBI Synonym Full Names: | upstream transcription factor 1 |
| NCBI Official Symbol: | USF1 |
| NCBI Official Synonym Symbols: | UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11 |
| NCBI Protein Information: | upstream stimulatory factor 1 |
| UniProt Protein Name: | Upstream stimulatory factor 1 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1 |
| Protein Family: | Upstream stimulatory factor |
| UniProt Gene Name: | USF1 |
| UniProt Entry Name: | USF1_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using USF1 antibody (CAB13560) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using USF1 antibody (CAB13560) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using USF1 antibody (CAB13560) at dilution of 1:200 (40x lens). |