Anti-USB1 Antibody (CAB13229)
- SKU:
- CAB13229
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-USB1 Antibody |
| 抗体コード: | CAB13229 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human USB1 (NP_078874.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, A-431, HeLa, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human USB1 (NP_078874.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSAA PLVG YSSS GSED ESED GMRT RPGD GSHR RGQS PLPR QRFP VPDS VLNM FPGT EEGP EDDS TKHG GRVR TFPH ERGN WATH VYVP YEAK EEFL DLLD VLLP HAQT YVPR LVRM KVFH LSLS QSVV LRHH WILP FVQA LKAR MTSF HRFF FTAN QVKI YTNQ EKTR TFIG LEVT SGHA QFLD LVSE VDRV MEEF NLTT FYQD PSFH LSLA WCVG DARL QLEG QCLQ ELQA IVDG FEDA EVLL RVHT EQVR CKSG NKFF SMPL K |
| 遺伝子ID: | 79650 |
| Uniprot: | Q9BQ65 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 20kDa/28kDa/30kDa |
| 観察された分子量: | 35kDa |
| 同義語: | USB1, C16orf57, HVSL1, Mpn1, PN, hUsb1 |
| バックグラウンド: | This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. |
| NCBI Summary: | This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q9BQ65 |
| NCBI GenInfo Identifier: | 306035177 |
| NCBI Gene ID: | 79650 |
| NCBI Accession: | NP_001182231.1 |
| UniProt Secondary Accession: | Q9BQ65,Q96FZ9, Q9H8X8, B4DWE3, B4DZW5, |
| UniProt Related Accession: | Q9BQ65 |
| Molecular Weight: | 20,802 Da |
| NCBI Full Name: | U6 snRNA phosphodiesterase isoform 2 |
| NCBI Synonym Full Names: | U6 snRNA biogenesis phosphodiesterase 1 |
| NCBI Official Symbol: | USB1 |
| NCBI Official Synonym Symbols: | PN; Mpn1; HVSL1; hUsb1; C16orf57 |
| NCBI Protein Information: | U6 snRNA phosphodiesterase |
| UniProt Protein Name: | U6 snRNA phosphodiesterase |
| Protein Family: | U6 snRNA phosphodiesterase |
| UniProt Gene Name: | USB1 |
 | Western blot analysis of extracts of various cell lines, using USB1 antibody (CAB13229) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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