Anti-Uroplakin-1b Antibody (CAB8157)
- SKU:
- CAB8157
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | UPK1B Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8157 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-230 of human UPK1B (NP_008883.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse skin |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-230 of human UPK1B (NP_008883.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ATQQ DFFT PNLF LKQM LERY QNNS PPNN DDQW KNNG VTKT WDRL MLQD NCCG VNGP SDWQ KYTS AFRT ENND ADYP WPRQ CCVM NNLK EPLN LEAC KLGV PGFY HNQG CYEL ISGP MNRH A |
| 遺伝子ID: | 7348 |
| Uniprot: | O75841 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 29kDa |
| 観察された分子量: | 28kDa |
| 同義語: | UPK1B, TSPAN20, UPIB, UPK1 |
| バックグラウンド: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. |
| UniProt Protein Function: | UPK1B: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Belongs to the tetraspanin (TM4SF) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q13.32 Cellular Component: integral to plasma membrane Biological Process: cell surface receptor linked signal transduction; epithelial cell differentiation |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75841 |
| NCBI GenInfo Identifier: | 313104322 |
| NCBI Gene ID: | 7348 |
| NCBI Accession: | O75841.5 |
| UniProt Secondary Accession: | O75841,O60753, Q9UIM2, Q9UNX6, |
| UniProt Related Accession: | O75841 |
| Molecular Weight: | 29,643 Da |
| NCBI Full Name: | Uroplakin-1b |
| NCBI Synonym Full Names: | uroplakin 1B |
| NCBI Official Symbol: | UPK1B |
| NCBI Official Synonym Symbols: | UPIB; UPK1; TSPAN20 |
| NCBI Protein Information: | uroplakin-1b |
| UniProt Protein Name: | Uroplakin-1b |
| UniProt Synonym Protein Names: | Tetraspanin-20; Tspan-20; Uroplakin Ib; UPIb |
| Protein Family: | Uroplakin |
| UniProt Gene Name: | UPK1B |
| UniProt Entry Name: | UPK1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UPK1B antibody (CAB8157) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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