Anti-UQCRQ Antibody (CAB9872)
- SKU:
- CAB9872
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-UQCRQ Antibody |
| 抗体コード: | CAB9872 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-82 of human UQCRQ (NP_055217.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | SW620, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-82 of human UQCRQ (NP_055217.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGRE FGNL TRMR HVIS YSLS PFEQ RAYP HVFT KGIP NVLR RIRE SFFR VVPQ FVVF YLIY TWGT EEFE RSKR KNPA AYEN DK |
| 遺伝子ID: | 27089 |
| Uniprot: | O14949 |
| セルラーロケーション: | Mitochondrion inner membrane |
| 計算された分子量: | 9kDa |
| 観察された分子量: | 12KDa |
| 同義語: | UQCRQ, MC3DN4, QCR8, QP-C, QPC, UQCR7 |
| バックグラウンド: | This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. |
| UniProt Protein Function: | UQCRQ: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. Defects in UQCRQ are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the UQCRQ/QCR8 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Oxidoreductase; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: mitochondrial inner membrane; mitochondrion Biological Process: mitochondrial electron transport, ubiquinol to cytochrome c Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 4 |
| NCBI Summary: | This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14949 |
| NCBI GenInfo Identifier: | 20141846 |
| NCBI Gene ID: | 27089 |
| NCBI Accession: | O14949.4 |
| UniProt Secondary Accession: | O14949,Q5FVE2, Q9BV88, Q9T2V7, |
| UniProt Related Accession: | O14949 |
| Molecular Weight: | 9,906 Da |
| NCBI Full Name: | Cytochrome b-c1 complex subunit 8 |
| NCBI Synonym Full Names: | ubiquinol-cytochrome c reductase complex III subunit VII |
| NCBI Official Symbol: | UQCRQ |
| NCBI Official Synonym Symbols: | QPC; QCR8; QP-C; UQCR7; MC3DN4 |
| NCBI Protein Information: | cytochrome b-c1 complex subunit 8 |
| UniProt Protein Name: | Cytochrome b-c1 complex subunit 8 |
| UniProt Synonym Protein Names: | Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
| UniProt Gene Name: | UQCRQ |
| UniProt Entry Name: | QCR8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UQCRQ Rabbit pAb (CAB9872) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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