Anti-UQCRB Antibody (CAB1273)
- SKU:
- CAB1273
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-UQCRB Antibody |
| 抗体コード: | CAB1273 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human UQCRB (NP_006285.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, MCF7, HL-60, HeLa, Mouse liver, Mouse small intestine, Mouse brain, Mouse kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human UQCRB (NP_006285.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGK QAVS ASGK WLDG IRKW YYNA AGFN KLGL MRDD TIYE DEDV KEAI RRLP ENLY NDRM FRIK RALD LNLK HQIL PKEQ WTKY EEEN FYLE PYLK EVIR ERKE REEW AKK |
| 遺伝子ID: | 7381 |
| Uniprot: | P14927 |
| セルラーロケーション: | Mitochondrion inner membrane |
| 計算された分子量: | 13kDa/16kDa |
| 観察された分子量: | 14kDa |
| 同義語: | UQCRB, MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC |
| バックグラウンド: | This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. |
| UniProt Protein Function: | UQCRB: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the UQCRB/QCR7 family. |
| UniProt Protein Details: | Protein type:Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Mitochondrial; EC 1.10.2.2 Chromosomal Location of Human Ortholog: 8q22 Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrial respiratory chain Biological Process: cellular metabolic process; aerobic respiration; mitochondrial electron transport, ubiquinol to cytochrome c; oxidative phosphorylation Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 3 |
| NCBI Summary: | This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P14927 |
| NCBI GenInfo Identifier: | 136717 |
| NCBI Gene ID: | 7381 |
| NCBI Accession: | P14927.2 |
| UniProt Secondary Accession: | P14927,Q6FGD1, E5RJU0, |
| UniProt Related Accession: | P14927 |
| Molecular Weight: | 16,267 Da |
| NCBI Full Name: | Cytochrome b-c1 complex subunit 7 |
| NCBI Synonym Full Names: | ubiquinol-cytochrome c reductase binding protein |
| NCBI Official Symbol: | UQCRB |
| NCBI Official Synonym Symbols: | QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3 |
| NCBI Protein Information: | cytochrome b-c1 complex subunit 7; complex III subunit 7; complex III subunit VII; mitochondrial ubiquinone-binding protein; ubiquinol-cytochrome c reductase complex 14 kDa protein; ubiquinol-cytochrome c reductase, complex III subunit VI |
| UniProt Protein Name: | Cytochrome b-c1 complex subunit 7 |
| UniProt Synonym Protein Names: | Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein |
| Protein Family: | Cytochrome b-c1 complex |
| UniProt Gene Name: | UQCRB |
| UniProt Entry Name: | QCR7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UQCRB antibody (CAB1273) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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