Anti-UGT2B15 Antibody (CAB16657)
- SKU:
- CAB16657
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-UGT2B15 Antibody |
| 抗体コード: | CAB16657 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human UGT2B15 (NP_001067.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, HepG2, MCF7, BT-474, LO2, mouse liver, rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human UGT2B15 (NP_001067.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ASTL VNAS KSSA IKLE VYPT SLTK NYLE DSLL KILD RWIY GVSK NTFW SYFS QLQE LCWE YYDY SNKL CKDA VLNK KLMM KLQE SKFD VILA DALN PCGE LLAE LFNI PFLY SLRF SVGY TFEK NGGG FLF |
| 遺伝子ID: | 7366 |
| Uniprot: | P54855 |
| セルラーロケーション: | |
| 計算された分子量: | 61kDa |
| 観察された分子量: | 61kDa |
| 同義語: | UGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8 |
| バックグラウンド: | This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. |
| UniProt Protein Function: | UGT2B15: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. Belongs to the UDP-glycosyltransferase family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - ascorbate and aldarate; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase Chromosomal Location of Human Ortholog: 4q13 Cellular Component: intracellular membrane-bound organelle Molecular Function:glucuronosyltransferase activity; retinoic acid binding Biological Process: flavonoid biosynthetic process; steroid metabolic process; xenobiotic metabolic process |
| NCBI Summary: | This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P54855 |
| NCBI GenInfo Identifier: | 332278237 |
| NCBI Gene ID: | 7366 |
| NCBI Accession: | P54855.3 |
| UniProt Secondary Accession: | P54855,P23765, Q9UK63, A6NDX0, A6NNJ4, A8K054, |
| UniProt Related Accession: | P54855,AAB28536 |
| Molecular Weight: | 61,036 Da |
| NCBI Full Name: | UDP-glucuronosyltransferase 2B15 |
| NCBI Synonym Full Names: | UDP glucuronosyltransferase family 2 member B15 |
| NCBI Official Symbol: | UGT2B15 |
| NCBI Official Synonym Symbols: | HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15 |
| NCBI Protein Information: | UDP-glucuronosyltransferase 2B15 |
| UniProt Protein Name: | UDP-glucuronosyltransferase 2B15 |
| UniProt Synonym Protein Names: | HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3 |
| Protein Family: | UDP-glucuronosyltransferase |
| UniProt Gene Name: | UGT2B15 |
| UniProt Entry Name: | UDB15_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UGT2B15 antibody (CAB16657) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human oophoroma using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens). |
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