Anti-UBE2V2 Antibody (CAB6998)
- SKU:
- CAB6998
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-UBE2V2 Antibody |
| 抗体コード: | CAB6998 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_003341.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SW480, SKOV3, HeLa, HL-60, Mouse liver, Mouse skin, Rat liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_003341.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAVS TGVK VPRN FRLL EELE EGQK GVGD GTVS WGLE DDED MTLT RWTG MIIG PPRT NYEN RIYS LKVE CGPK YPEA PPSV RFVT KINM NGIN NSSG MVDA RSIP VLAK WQNS YSIK VVLQ ELRR LMMS KENM KLPQ PPEG QTYN N |
| 遺伝子ID: | 7336 |
| Uniprot: | Q15819 |
| セルラーロケーション: | |
| 計算された分子量: | 16kDa |
| 観察された分子量: | 16kDa |
| 同義語: | UBE2V2, DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 |
| バックグラウンド: | Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. |
| UniProt Protein Function: | UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q11.21 Cellular Component: cytoplasm; nucleus; UBC13-MMS2 complex Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding Biological Process: regulation of DNA repair; positive regulation of synaptogenesis; cell proliferation; protein polyubiquitination; positive regulation of DNA repair; postreplication repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA double-strand break processing; protein ubiquitination; negative regulation of neuron apoptosis |
| NCBI Summary: | Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15819 |
| NCBI GenInfo Identifier: | 51701935 |
| NCBI Gene ID: | 7336 |
| NCBI Accession: | Q15819.4 |
| UniProt Related Accession: | Q15819 |
| Molecular Weight: | 145 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 variant 2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2 variant 2 |
| NCBI Official Symbol: | UBE2V2 |
| NCBI Official Synonym Symbols: | MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1 |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; MMS2 homolog; vitamin D3-inducible protein; 1 alpha,25-dihydroxyvitamin D3-inducible; enterocyte differentiation promoting factor; enterocyte differentiation-promoting factor 1; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 variant 2 |
| UniProt Synonym Protein Names: | DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2V2 |
| UniProt Entry Name: | UB2V2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBE2V2 antibody (CAB6998) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using UBE2V2 antibody (CAB6998) at dilution of 1:100 (40x lens). |
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