Anti-UBE2R2 Antibody (CAB7373)
- SKU:
- CAB7373
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-UBE2R2 Antibody |
| 抗体コード: | CAB7373 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human UBE2R2 (NP_060281.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, MCF7, Mouse liver, Mouse kidney, Mouse heart, Rat brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human UBE2R2 (NP_060281.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAQQ QMTS SQKA LMLE LKSL QEEP VEGF RITL VDES DLYN WEVA IFGP PNTL YEGG YFKA HIKF PIDY PYSP PTFR FLTK MWHP NIYE NGDV CISI LHPP VDDP QSGE LPSE RWNP TQNV RTIL LSVI SLLN EPNT FSPA NVDA SVMF RKWR DSKG KDKE YAEI IRKQ VSAT KAEA EKDG VKVP TTLA EYCI KTKV PSND NSSD LLYD DLYD DDID DEDE EEED ADCY DDDD SGNE ES |
| 遺伝子ID: | 54926 |
| Uniprot: | Q712K3 |
| セルラーロケーション: | |
| 計算された分子量: | 27kDa |
| 観察された分子量: | 27kDa |
| 同義語: | UBE2R2, CDC34B, E2-CDC34B, UBC3B |
| バックグラウンド: | Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. |
| UniProt Protein Function: | UBC3B: an E2 ubiquitin conjugating enzyme similar to UBC3/CDC34. Phosphorylation of UBC3B by CK2 induces its interaction with beta-TrCP, regulating beta-TrCP substrate recognition and enhancing beta-catenin degradation. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: cytoplasm Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process |
| NCBI Summary: | Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q712K3 |
| NCBI GenInfo Identifier: | 74749761 |
| NCBI Gene ID: | 54926 |
| NCBI Accession: | Q712K3.1 |
| UniProt Secondary Accession: | Q712K3,Q9NX64, D3DRL5, |
| UniProt Related Accession: | Q712K3 |
| Molecular Weight: | 238 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 R2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2R 2 |
| NCBI Official Symbol: | UBE2R2 |
| NCBI Official Synonym Symbols: | UBC3B; CDC34B; E2-CDC34B |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 R2; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 R2 |
| UniProt Synonym Protein Names: | Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2 |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2R2 |
| UniProt Entry Name: | UB2R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBE2R2 antibody (CAB7373) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded mouse cancer using UBE2R2 antibody (CAB7373) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using UBE2R2 antibody (CAB7373). |
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