Anti-Ube2N / Ubc13 Antibody (CAB9257)
- SKU:
- CAB9257
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-Ube2N / Ubc13 Antibody |
抗体コード: | CAB9257 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Ube2N / Ubc13 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HCT116, 293T, C6, Mouse testis, Mouse brain, Rat testis, Rat brain |
免疫原: | A synthesized peptide derived from human Ube2N / Ubc13 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 7334 |
Uniprot: | P61088 |
セルラーロケーション: | |
計算された分子量: | 17kDa |
観察された分子量: | 17KDa |
同義語: | HEL-S-71, UBC13, UBCHBEN, UBC13, UbcH-ben, UbcH13 |
バックグラウンド: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61088 |
NCBI GenInfo Identifier: | 46577660 |
NCBI Gene ID: | 7334 |
NCBI Accession: | P61088.1 |
UniProt Secondary Accession: | P61088,Q16781, Q53Y81, |
UniProt Related Accession: | P61088 |
Molecular Weight: | 17kDa |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 N |
NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 N |
NCBI Official Symbol: | UBE2N |
NCBI Official Synonym Symbols: | UBC13; UbcH13; HEL-S-71; UbcH-ben; UBCHBEN; UBC13 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 N |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 N |
UniProt Synonym Protein Names: | Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2N |
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