| UniProt Protein Function: | Tyro3: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TUB, TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. Abundant in the brain and lower levels in other tissues. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Axl family Chromosomal Location of Human Ortholog: 15q15 Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; nuclear envelope; nucleus Molecular Function:protein binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: forebrain cell migration; platelet activation; negative regulation of lymphocyte activation; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; vagina development; signal transduction; ovulation cycle; negative regulation of innate immune response; natural killer cell differentiation; negative regulation of inflammatory response; protein kinase B signaling cascade; negative regulation of toll-like receptor signaling pathway; spermatogenesis; negative regulation of neuron apoptosis; cell adhesion; apoptotic cell clearance; secretion by cell |
| NCBI Summary: | The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] |
| UniProt Code: | Q06418 |
| NCBI GenInfo Identifier: | 1717829 |
| NCBI Gene ID: | 7301 |
| NCBI Accession: | Q06418.1 |
| UniProt Secondary Accession: | Q06418,O14953, Q86VR3, |
| UniProt Related Accession: | Q06418 |
| Molecular Weight: | 96,905 Da |
| NCBI Full Name: | Tyrosine-protein kinase receptor TYRO3 |
| NCBI Synonym Full Names: | TYRO3 protein tyrosine kinase |
| NCBI Official Symbol: | TYRO3 |
| NCBI Official Synonym Symbols: | BYK; Dtk; RSE; Sky; Tif |
| NCBI Protein Information: | tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase TIF; tyrosine-protein kinase byk |
| UniProt Protein Name: | Tyrosine-protein kinase receptor TYRO3 |
| UniProt Synonym Protein Names: | Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF |
| UniProt Gene Name: | TYRO3 |
| UniProt Entry Name: | TYRO3_HUMAN |
