Anti-TYMP Antibody (CAB1094)
- SKU:
- CAB1094
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-TYMP Antibody |
| 抗体コード: | CAB1094 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TYMP (NP_001107228.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, THP-1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TYMP (NP_001107228.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAL MTPG TGAP PAPG DFSG EGSQ GLPD PSPE PKQL PELI RMKR DGGR LSEA DIRG FVAA VVNG SAQG AQIG AMLM AIRL RGMD LEET SVLT QALA QSGQ QLEW PEAW RQQL VDKH STGG VGDK VSLV LAPA LAAC GCKV PMIS GRGL GHTG GTLD KLES IPGF NVIQ SPEQ MQVL LDQA GCCI VGQS EQLV PADG ILYA |
| 遺伝子ID: | 1890 |
| Uniprot: | P19971 |
| セルラーロケーション: | |
| 計算された分子量: | 49kDa/50kDa |
| 観察された分子量: | 50kDa |
| 同義語: | TYMP, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF |
| バックグラウンド: | This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. |
| UniProt Protein Function: | ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine; EC 2.4.2.4; Phosphorylase; DNA replication; Transferase; Cytokine; Xenobiotic Metabolism - drug metabolism - other enzymes Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: cytosol Molecular Function:phosphorylase activity; platelet-derived growth factor receptor binding; transferase activity, transferring pentosyl groups Biological Process: DNA replication; mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type) |
| NCBI Summary: | This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P19971 |
| NCBI GenInfo Identifier: | 67477361 |
| NCBI Gene ID: | 1890 |
| NCBI Accession: | P19971.2 |
| UniProt Secondary Accession: | P19971,Q13390, Q8WVB7, A8MW15, H9KVA0, |
| UniProt Related Accession: | P19971 |
| Molecular Weight: | 50,405 Da |
| NCBI Full Name: | Thymidine phosphorylase |
| NCBI Synonym Full Names: | thymidine phosphorylase |
| NCBI Official Symbol: | TYMP |
| NCBI Official Synonym Symbols: | TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF |
| NCBI Protein Information: | thymidine phosphorylase |
| UniProt Protein Name: | Thymidine phosphorylase |
| UniProt Synonym Protein Names: | Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase |
| UniProt Gene Name: | TYMP |
| UniProt Entry Name: | TYPH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TYMP antibody (CAB1094) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of HeLa cells using TYMP antibody (CAB1094). Blue: DAPI for nuclear staining. |
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