Anti-TXNDC5 Antibody (CAB14152)
- SKU:
- CAB14152
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TXNDC5 Antibody |
| 抗体コード: | CAB14152 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human TXNDC5 (NP_001139021.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, NCI-H460 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human TXNDC5 (NP_001139021.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEDA KVYV AKVD CTAH SDVC SAQG VRGY PTLK LFKP GQEA VKYQ GPRD FQTL ENWM LQTL NEEP VTPE PEVE PPSA PELK QGLY ELSA SNFE LHVA QGDH FIKF FAPW CGHC KALA PTWE QLAL GLEH SETV KIGK VDCT QHYE LCSG NQVR GYPT LLWF RDGK KVDQ YKGK RDLE SLRE YVES QLQR TETG ATET VTPS EAPV LAAE PEAD KGTV LALT ENNF DDTI AEGI TFIK FYAP WCGH CKTL APTW EELS KKEF PGLA GVKI AEVD CTAE RNIC SKYS VRGY PTLL LFRG GKKV SEHS GGRD LDSL HRFV LSQA KDEL |
| 遺伝子ID: | 81567 |
| Uniprot: | Q8NBS9 |
| セルラーロケーション: | Endoplasmic reticulum lumen |
| 計算された分子量: | 36kDa/47kDa |
| 観察された分子量: | 48kDa |
| 同義語: | TXNDC5, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 |
| バックグラウンド: | This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. |
| UniProt Protein Function: | TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q8NBS9 |
| NCBI GenInfo Identifier: | 29839560 |
| NCBI Gene ID: | 81567 |
| NCBI Accession: | Q8NBS9.2 |
| UniProt Related Accession: | Q8NBS9 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin domain-containing protein 5 |
| NCBI Synonym Full Names: | thioredoxin domain containing 5 |
| NCBI Official Symbol: | TXNDC5 |
| NCBI Official Synonym Symbols: | HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI |
| NCBI Protein Information: | thioredoxin domain-containing protein 5 |
| UniProt Protein Name: | Thioredoxin domain-containing protein 5 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46 |
| UniProt Gene Name: | TXNDC5 |
| UniProt Entry Name: | TXND5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TXNDC5 antibody (CAB14152) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using TXNDC5 Antibody (CAB14152) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using TXNDC5 Antibody (CAB14152) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using TXNDC5 antibody (CAB14152). Blue: DAPI for nuclear staining. |
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