Anti-TUG/ASPSCR1 Antibody (CAB1396)

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SKU:
CAB1396
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ASPSCR1
Synonyms:
ASPCR1
Synonyms:
ASPL
Synonyms:
ASPS
Synonyms:
RCC17
Synonyms:
TUG
Synonyms:
UBXD9
Synonyms:
UBXN9
Synonyms:
tether containing UBX domain for GLUT4
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Description

抗体名:TUG/ASPSCR1 Rabbit mAb
抗体コード:CAB1396
サイズ:20uL, 50uL, 100uL
同義語:ASPSCR1, ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9, tether containing UBX domain for GLUT4
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:A synthesized peptide derived from human TUG/ASPSCR1.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:293T, NIH/3T3, RD, Mouse testis
免疫原:A synthesized peptide derived from human TUG/ASPSCR1.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:79058
Uniprot:Q9BZE9
セルラーロケーション:Cytoplasm, Endomembrane system, Endoplasmic reticulum-Golgi intermediate compartment membrane, Nucleus, Peripheral membrane protein
計算された分子量:70-80kDa
観察された分子量:75KDa
UniProt Protein Function:ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oncoprotein; Membrane protein, peripheral; Vesicle

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function:protein binding

Disease: Alveolar Soft Part Sarcoma

NCBI Summary:The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
UniProt Code:Q9BZE9
NCBI GenInfo Identifier:74717746
NCBI Gene ID:79058
NCBI Accession:Q9BZE9.1
UniProt Secondary Accession:Q9BZE9,Q7Z6N7, Q8WV59, Q96LS5, Q96M40, A8K3K9,
UniProt Related Accession:Q9BZE9
Molecular Weight:37,910 Da
NCBI Full Name:Tether containing UBX domain for GLUT4
NCBI Synonym Full Names:ASPSCR1, UBX domain containing tether for SLC2A4
NCBI Official Symbol:ASPSCR1  
NCBI Official Synonym Symbols:TUG; ASPL; ASPS; RCC17; UBXD9; UBXN9; ASPCR1  
NCBI Protein Information:tether containing UBX domain for GLUT4
UniProt Protein Name:Tether containing UBX domain for GLUT4
UniProt Synonym Protein Names:Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9
Protein Family:Tether containing UBX domain
UniProt Gene Name:ASPSCR1  
UniProt Entry Name:ASPC1_HUMAN
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