Anti-TSHZ3 Antibody (CAB18479)
- SKU:
- CAB18479
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-TSHZ3 Antibody |
抗体コード: | CAB18479 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human TSHZ3. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, HepG2 |
免疫原: | Recombinant protein of human TSHZ3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 57616 |
Uniprot: | Q63HK5 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 119kDa |
同義語: | TSH3, ZNF537, TSHZ3 |
バックグラウンド: |
UniProt Protein Function: | Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation. |
NCBI Summary: | This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q63HK5 |
NCBI GenInfo Identifier: | 127138957 |
NCBI Gene ID: | 57616 |
NCBI Accession: | NP_065907.2 |
UniProt Secondary Accession: | Q63HK5,Q9H0G6, Q9P254, A1L0U7, |
UniProt Related Accession: | Q63HK5 |
Molecular Weight: | 118 |
NCBI Full Name: | teashirt homolog 3 |
NCBI Synonym Full Names: | teashirt zinc finger homeobox 3 |
NCBI Official Symbol: | TSHZ3 |
NCBI Official Synonym Symbols: | TSH3; ZNF537 |
NCBI Protein Information: | teashirt homolog 3 |
UniProt Protein Name: | Teashirt homolog 3 |
UniProt Synonym Protein Names: | Zinc finger protein 537 |
UniProt Gene Name: | TSHZ3 |