Anti-TSC22D3 Antibody (CAB19911)[KO Validated]
- SKU:
- CAB19911
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-TSC22D3 Antibody [KO Validated] |
抗体コード: | CAB19911 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human TSC22D3. |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human TSC22D3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 1831 |
Uniprot: | Q99576 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 13kDa/14kDa/22kDa |
観察された分子量: | 16KDa |
同義語: | TSC22D3, DIP, DSIPI, GILZ, TSC-22R |
バックグラウンド: | This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor ?B. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq22.3 Cellular Component: cytosol Biological Process: regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q99576 |
NCBI GenInfo Identifier: | 14195584 |
NCBI Gene ID: | 1831 |
NCBI Accession: | Q99576.2 |
UniProt Secondary Accession: | Q99576,Q5H9S3, Q5JRI9, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5 Q9UG13, |
UniProt Related Accession: | Q99576 |
Molecular Weight: | 13,286 Da |
NCBI Full Name: | TSC22 domain family protein 3 |
NCBI Synonym Full Names: | TSC22 domain family member 3 |
NCBI Official Symbol: | TSC22D3 |
NCBI Official Synonym Symbols: | DIP; GILZ; DSIPI; TSC-22R |
NCBI Protein Information: | TSC22 domain family protein 3 |
UniProt Protein Name: | TSC22 domain family protein 3 |
UniProt Synonym Protein Names: | DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R |
Protein Family: | TSC22 domain family protein |
UniProt Gene Name: | TSC22D3 |
UniProt Entry Name: | T22D3_HUMAN |